MolNFT v1 · #137108 · protein

Crystal structure of sugen kinase 223

5VE6 · Tyrosine-protein kinase SGK223: “Crystal structure of sugen kinase 223”. X-ray diffraction, 5 pockets (best druggability 0.35). MolNFT v1 #137108 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5VE6
Type: protein
Length: 348 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein kinase SGK223
EC: 2.7.10.2
UniProt: Q86YV5
Pockets: 5 · best druggability 0.35

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein kinase SGK223 (EC 2.7.10.2)	protein	348	49% helix, 15% strand	Q86YV5

Pockets

5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	91	0.35	0.75	19	empty
2	81	0.34	0.75	18	empty
3	55	0.32	0.77	20	empty
4	65	0.30	0.74	15	empty
5	52	0.27	0.74	11	empty

Compared structures

5VE6 · Crystal structure of Sugen kinase 223 · the same entry in another collection · chain A against A, TM-score 1.00
Q86YV5 · AlphaFold monomer V2.0 prediction for inactive tyrosine-protein kinase PRAG1 (Q86YV5) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q86YV5
Elsewhere: RCSB PDB 5VE6 · PDBe 5VE6 · UniProt Q86YV5

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