MolNFT v1 · #137103 · protein

Human cyclic gmp-AMP synthase (cgas) in complex with compound F1

5VDW: “Human cyclic gmp-AMP synthase (cgas) in complex with compound F1”. X-ray diffraction, 2 ligands (9BY, ZN). MolNFT v1 #137103 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5VDW
Type: protein
Length: 720 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q8N884
Ligands: 9BY, ZN

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	—	protein	360	—	Q8N884

Ligands and binding sites

9BY · [2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetic acid · ligand · 2 copies · chains A, B
ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5VDW · Human cyclic GMP-AMP synthase (cGAS) in complex with Compound F1 · the same entry in another collection · chain A against A, TM-score 1.00
Q8N884 · AlphaFold monomer V2.0 prediction for cyclic gmp-AMP synthase (Q8N884) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8N884
Elsewhere: RCSB PDB 5VDW · PDBe 5VDW · UniProt Q8N884

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