MolNFT v1 · #137057 · protein

Crystal structure of full-length kluyveromyces lactis KAP123

5VCH: “Crystal structure of full-length kluyveromyces lactis KAP123”. X-ray diffraction, 19 pockets (best druggability 0.71). MolNFT v1 #137057 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5VCH
Type: protein
Length: 2,047 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: KAP123
UniProt: Q6CMF0
Pockets: 19 · best druggability 0.71

Structure

x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	KAP123	protein	1020	78% helix, 0% strand	Q6CMF0
B	KAP123	protein	1027	78% helix, 0% strand	Q6CMF0

Pockets

19 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	822	0.71	0.77	109	empty
2	576	0.68	0.77	55	empty
3	355	0.61	0.78	45	empty
4	324	0.60	0.78	39	empty
5	480	0.58	0.74	56	empty

Interfaces

1 interface between chains.

A–B · 503 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 22 modified (engineered).

Compared structures

5VCH · Crystal structure of full-length Kluyveromyces lactis Kap123 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6CMF0
Elsewhere: RCSB PDB 5VCH · PDBe 5VCH · UniProt Q6CMF0

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