MolNFT v1 · #136960 · protein

Structure of the H477R variant of rat cytosolic pepck in complex with manganese.

5V95 · Phosphoenolpyruvate carboxykinase, cytosolic [GTP]: “Structure of the H477R variant of rat cytosolic pepck in complex with manganese.”. X-ray diffraction, 2 ligands (MN, NA), 8 pockets (best druggability 0.61). MolNFT v1 #136960 on…

PDB: 5V95
Type: protein
Length: 592 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
EC: 4.1.1.32
UniProt: P07379
Ligands: MN, NA
Pockets: 8 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (EC 4.1.1.32)	protein	592	30% helix, 23% strand	P07379

Ligands and binding sites

MN · Manganese (II) ion · metal · 2 copies · chains A
NA · Sodium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	197	0.61	0.82	31	MN
2	147	0.59	0.83	21	empty
3	121	0.53	0.82	33	empty
4	69	0.45	0.82	24	empty
5	64	0.44	0.82	19	empty

Compared structures

5V95 · Structure of the H477R variant of rat cytosolic PEPCK in complex with manganese. · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07379
Elsewhere: RCSB PDB 5V95 · PDBe 5V95 · UniProt P07379

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