MolNFT v1 · #136957 · protein

Crystal structure of fosfomycin resistance protein from klebsiella pneumoniae

5V91: “Crystal structure of fosfomycin resistance protein from klebsiella pneumoniae”. X-ray diffraction, 1 ligand (ZN), 4 pockets (best druggability 0.68). MolNFT v1 #136957 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5V91
Type: protein
Length: 276 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fosfomycin resistance protein
UniProt: W8UNW6
Ligands: ZN
Pockets: 4 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Fosfomycin resistance protein	protein	138	27% helix, 34% strand	W8UNW6

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	303	0.68	0.83	25	empty
2	118	0.50	0.81	22	empty
3	56	0.35	0.78	11	empty
4	51	0.33	0.78	16	empty

Interfaces

1 interface between chains.

A–B · 2802 Å² buried · 50 hydrogen bonds · protein-protein

Compared structures

5V91 · Crystal structure of fosfomycin resistance protein from Klebsiella pneumoniae · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt W8UNW6
Elsewhere: RCSB PDB 5V91 · PDBe 5V91 · UniProt W8UNW6

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