MolNFT v1 · #136925 · protein

Ssnmr structure of the human RIP1/RIP3 necrosome

5V7Z · Pro-leu-val-asn-ile-tyr-asn-cys-ser-gly-val-gln-val-gly- asp: “Ssnmr structure of the human RIP1/RIP3 necrosome”. Solid-state nmr, 1 pocket (best druggability 0.29). MolNFT v1 #136925 on GenesisL1: 3D structure, binding sites and…

PDB: 5V7Z
Type: protein
Length: 132 residues
Chains: 8
Method: solid-state nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pro-leu-val-asn-ile-tyr-asn-cys-ser-gly-val-gln-val-gly- asp…
Pockets: 1 · best druggability 0.29

Structure

solid-state nmr · 2 distinct chains · 0% helix, 61% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, E, G	Pro-leu-val-asn-ile-tyr-asn-cys-ser-gly-val-gln-val-gly- asp	protein	15	0% helix, 67% strand	—
B, D, F, H	Thr-ile-tyr-asn-ser-thr-gly-ile-gln-ile-gly-ala-tyr-asn- tyr-met-glu-ile	protein	18	0% helix, 56% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	64	0.29	0.74	11	empty

Interfaces

20 interfaces between chains.

A–B · 602 Å² buried · 21 hydrogen bonds · protein-protein
C–D · 567 Å² buried · 15 hydrogen bonds · protein-protein
G–H · 551 Å² buried · 18 hydrogen bonds · protein-protein
E–F · 544 Å² buried · 18 hydrogen bonds · protein-protein
D–G · 544 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

5V7Z · SSNMR Structure of the Human RIP1/RIP3 Necrosome · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5V7Z · PDBe 5V7Z

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