MolNFT v1 · #136917 · protein
Cyrstal structure of anti-tau antibody cbtau-7.1 Fab
5V7R · Cbtau-7.1 Fab light chain: “Cyrstal structure of anti-tau antibody cbtau-7.1 Fab”. X-ray diffraction, 5 pockets (best druggability 0.58). MolNFT v1 #136917 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5V7R
- Type
- protein
- Length
- 434 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cbtau-7.1 Fab light chain; Cbtau-7.1 Fab heavy chain
- Pockets
- 5 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Cbtau-7.1 Fab light chain | protein | 215 | 6% helix, 49% strand | — |
| H | Cbtau-7.1 Fab heavy chain | protein | 219 | 4% helix, 52% strand | — |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 207 | 0.58 | 0.80 | 30 | empty |
| 2 | 450 | 0.57 | 0.74 | 53 | empty |
| 3 | 116 | 0.39 | 0.75 | 27 | empty |
| 4 | 70 | 0.34 | 0.76 | 18 | empty |
| 5 | 88 | 0.32 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- L–H · 1887 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 5V7R · Cyrstal structure of anti-Tau antibody CBTAU-7.1 Fab · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5V7R · PDBe 5V7R
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.