MolNFT v1 · #136874 · protein

Crystal structure of influenza a virus matrix protein M1(NLS-88R)

5V6G · Matrix protein 1: “Crystal structure of influenza a virus matrix protein M1(NLS-88R)”. X-ray diffraction, 5 pockets (best druggability 0.76). MolNFT v1 #136874 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5V6G
Type: protein
Length: 628 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Matrix protein 1
UniProt: P05777
Pockets: 5 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Matrix protein 1	protein	157	70% helix, 0% strand	P05777

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	567	0.76	0.83	63	empty
2	475	0.72	0.81	49	empty
3	115	0.51	0.81	31	empty
4	76	0.37	0.77	17	empty
5	68	0.34	0.76	15	empty

Interfaces

6 interfaces between chains.

C–D · 1211 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 1190 Å² buried · 13 hydrogen bonds · protein-protein
B–C · 669 Å² buried · 7 hydrogen bonds · protein-protein
A–D · 611 Å² buried · 3 hydrogen bonds · protein-protein
A–C · 42 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

5V6G · Crystal structure of Influenza A virus Matrix Protein M1(NLS-88R) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P05777
Elsewhere: RCSB PDB 5V6G · PDBe 5V6G · UniProt P05777

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