MolNFT v1 · #136869 · protein

Crystal structure of GIPC1

5V6B · PDZ domain-containing protein GIPC1: “Crystal structure of GIPC1”. X-ray diffraction, 8 pockets (best druggability 0.67). MolNFT v1 #136869 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5V6B
Type: protein
Length: 523 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: PDZ domain-containing protein GIPC1
UniProt: Q9Z0G0
Pockets: 8 · best druggability 0.67

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	PDZ domain-containing protein GIPC1	protein	262	31% helix, 27% strand	Q9Z0G0
B	PDZ domain-containing protein GIPC1	protein	261	33% helix, 26% strand	Q9Z0G0

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	114	0.67	0.90	28	empty
2	51	0.67	0.96	19	empty
3	411	0.65	0.79	39	empty
4	122	0.65	0.88	31	empty
5	380	0.64	0.79	38	empty

Interfaces

1 interface between chains.

A–B · 4465 Å² buried · 80 hydrogen bonds · protein-protein

Compared structures

5V6B · Crystal structure of GIPC1 · the same entry in another collection · chain A against A, TM-score 1.00
Q9Z0G0 · AlphaFold monomer V2.0 prediction for PDZ domain-containing protein GIPC1 (Q9Z0G0) · a predicted model of the same protein · chain B against A, TM-score 0.60

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Z0G0
Elsewhere: RCSB PDB 5V6B · PDBe 5V6B · UniProt Q9Z0G0

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