MolNFT v1 · #136843 · protein

Crystal structure of ferritin E65R mutant from hyperthermophilic archaeon archaeoglobus fulgidus

5V5K: “Crystal structure of ferritin E65R mutant from hyperthermophilic archaeon archaeoglobus fulgidus”. X-ray diffraction, 15 pockets (best druggability 0.76). MolNFT v1 #136843 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 5V5K
Type: protein
Length: 1,296 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ferritin
UniProt: O29424
Pockets: 15 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H	Ferritin	protein	162	31% helix, 1% strand	O29424

Pockets

15 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	545	0.76	0.83	76	empty
2	574	0.75	0.83	92	empty
3	960	0.74	0.78	88	empty
4	647	0.73	0.80	90	empty
5	599	0.72	0.80	93	empty

Interfaces

13 interfaces between chains.

C–D · 432 Å² buried · 1 hydrogen bond · protein-protein
F–G · 388 Å² buried · 2 hydrogen bonds · protein-protein
A–H · 325 Å² buried · 2 hydrogen bonds · protein-protein
B–F · 185 Å² buried · 0 hydrogen bonds · protein-protein
C–E · 167 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

5V5K · Crystal structure of ferritin E65R mutant from hyperthermophilic archaeon Archaeoglobus… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O29424
Elsewhere: RCSB PDB 5V5K · PDBe 5V5K · UniProt O29424

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