MolNFT v1 · #136796 · protein
Crystal structure of the F270M, K291M, L318M mutant of SR1 domain of human sacsin
5V45: “Crystal structure of the F270M, K291M, L318M mutant of SR1 domain of human sacsin”. X-ray diffraction, 4 pockets (best druggability 0.73). MolNFT v1 #136796 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5V45
- Type
- protein
- Length
- 472 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sacsin
- UniProt
- Q9NZJ4
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sacsin | protein | 237 | 32% helix, 22% strand | Q9NZJ4 |
| B | Sacsin | protein | 235 | 37% helix, 22% strand | Q9NZJ4 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 526 | 0.73 | 0.81 | 53 | empty |
| 2 | 235 | 0.57 | 0.79 | 39 | empty |
| 3 | 108 | 0.44 | 0.78 | 20 | empty |
| 4 | 53 | 0.27 | 0.73 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 708 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 5V45 · Crystal structure of the F270M, K291M, L318M mutant of SR1 domain of human sacsin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NZJ4
- Elsewhere: RCSB PDB 5V45 · PDBe 5V45 · UniProt Q9NZJ4
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