MolNFT v1 · #136794 · protein

Engineered human IgG Fc domain AGLYCO801

5V43 · Ig gamma-1 chain C region: “Engineered human IgG Fc domain AGLYCO801”. X-ray diffraction, 8 pockets (best druggability 0.46). MolNFT v1 #136794 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5V43
Type: protein
Length: 411 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ig gamma-1 chain C region
UniProt: P01857
Pockets: 8 · best druggability 0.46

Structure

x-ray diffraction · 2 distinct chains · 10% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ig gamma-1 chain C region	protein	209	11% helix, 48% strand	P01857
B	Ig gamma-1 chain C region	protein	202	9% helix, 49% strand	P01857

Pockets

8 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	210	0.46	0.73	24	empty
2	66	0.40	0.80	13	empty
3	97	0.37	0.75	22	empty
4	63	0.34	0.76	19	empty
5	57	0.34	0.77	16	empty

Interfaces

1 interface between chains.

A–B · 1574 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5V43 · Engineered human IgG Fc domain aglyco801 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01857
Elsewhere: RCSB PDB 5V43 · PDBe 5V43 · UniProt P01857

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