Crystal structure of SMYD2 with SAM and EPZ033294

Structure

x-ray diffraction · 1 distinct chain.

Ligands and binding sites

• 8WG · N-[1-({1-[(4-chlorophenyl)methyl]-1H-pyrazol-4-yl}methyl)azetidin-3-yl]-1-cyclopropyl-1H-1,2,3-triazole-4-carboxamide · ligand · 2 copies · chains A
• ZN · Zinc ion · metal · 3 copies · chains A
• PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A
• GOL · Glycerol · additive · 2 copies · chains A
• EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5V3H · Crystal structure of SMYD2 with SAM and EPZ033294 · the same entry in another collection · chain A against A, TM-score 1.00
• Q9NRG4 · AlphaFold monomer V2.0 prediction for N-lysine methyltransferase SMYD2 (Q9NRG4) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9NRG4
• Elsewhere: RCSB PDB 5V3H · PDBe 5V3H · UniProt Q9NRG4