MolNFT v1 · #136658 · protein + RNA
Structure of wild type pre-MIR21 apical loop
5UZZ: “Structure of wild type pre-MIR21 apical loop”. Solution nmr, 2 pockets (best druggability 0.56). MolNFT v1 #136658 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5UZZ
- Type
- protein + RNA
- Length
- 45 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pre-MIR21; 14-mer peptide
- Pockets
- 2 · best druggability 0.56
Structure
solution nmr · 2 distinct chains · 0% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pre-MIR21 | rna | 31 | — | — |
| B | 14-mer peptide | protein | 14 | 0% helix, 57% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 278 | 0.56 | 0.78 | 25 | empty |
| 2 | 109 | 0.34 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 650 Ų buried · 20 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 1 d-amino (D-amino acid).
Compared structures
- 5UZZ · Structure of wild type pre-miR21 apical loop · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5UZZ · PDBe 5UZZ
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