MolNFT v1 · #136529 · protein

BRD4 bromodomain 2 with a-1359643

5UVX: “BRD4 bromodomain 2 with a-1359643”. X-ray diffraction, 1 ligand (8NM). MolNFT v1 #136529 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5UVX
Type: protein
Length: 213 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: O60885
Ligands: 8NM

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	108	—	O60885
B	—	protein	105	—	O60885

Ligands and binding sites

8NM · N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxyphenyl]methanesulfonamide · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5UVX · BRD4 Bromodomain 2 with A-1359643 · the same entry in another collection · chain A against A, TM-score 1.00
O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O60885
Elsewhere: RCSB PDB 5UVX · PDBe 5UVX · UniProt O60885

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