MolNFT v1 · #136528 · protein

BRD4_BROMODOMAIN1-A1376855

5UVW: “BRD4_BROMODOMAIN1-A1376855”. X-ray diffraction, 2 ligands (8NG, SO4). MolNFT v1 #136528 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5UVW
Type: protein
Length: 324 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: O60885
Ligands: 8NG, SO4

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	—	protein	109	—	O60885
B	—	protein	106	—	O60885

Ligands and binding sites

8NG · N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl) phenyl]ethanesulfonamide · ligand · 3 copies · chains A, B, C
SO4 · Sulfate ion · ion · 2 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5UVW · BRD4_Bromodomain1-A1376855 · the same entry in another collection · chain A against A, TM-score 1.00
O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O60885
Elsewhere: RCSB PDB 5UVW · PDBe 5UVW · UniProt O60885

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