MolNFT v1 · #136416 · protein + DNA

Crystal structure of schizosaccharomyces pombe POT1PC bound to SSRNA/SSDNA chimera (rggttacggt)

5USB · Protection of telomeres protein 1: “Crystal structure of schizosaccharomyces pombe POT1PC bound to SSRNA/SSDNA chimera (rggttacggt)”. X-ray diffraction, 2 pockets (best druggability 0.45). MolNFT v1 #136416 on GenesisL1: 3D…

PDB: 5USB
Type: protein + DNA
Length: 148 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protection of telomeres protein 1; G1R_9MER DNA/RNA…
UniProt: O13988
Pockets: 2 · best druggability 0.45

Structure

x-ray diffraction · 2 distinct chains · 16% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protection of telomeres protein 1	protein	139	16% helix, 34% strand	O13988
B	G1R_9MER DNA/RNA (5'-R(G)-D(PGPTPTPAPCPGPGP*T)-3')	dna	9	—	—

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	103	0.45	0.79	14	empty
2	63	0.42	0.81	17	empty

Interfaces

1 interface between chains.

A–B · 1074 Å² buried · 31 hydrogen bonds · protein-nucleic

Compared structures

5USB · Crystal Structure of Schizosaccharomyces pombe Pot1pC bound to ssRNA/ssDNA chimera… · the same entry in another collection · chain A against A, TM-score 1.00
O13988 · AlphaFold monomer V2.0 prediction for protection of telomeres protein 1 (O13988) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O13988
Elsewhere: RCSB PDB 5USB · PDBe 5USB · UniProt O13988

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