MolNFT v1 · #136190 · protein
Crystal structure of the first bromodomain of human BRD4 in complex with cyclic vinylogous amide inhibitor MS402
5ULA: “Crystal structure of the first bromodomain of human BRD4 in complex with cyclic vinylogous amide inhibitor…”. X-ray diffraction, 1 ligand (5MJ). MolNFT v1 #136190 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5ULA
- Type
- protein
- Length
- 241 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O60885
- Ligands
- 5MJ
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 119 | — | O60885 |
| B | — | protein | 122 | — | O60885 |
Ligands and binding sites
- 5MJ · 3-chloranyl-~{N}-(4-methoxyphenyl)-4-[(2-methyl-3-oxidanylidene-cyclopenten-1-yl)amino]benzamide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5ULA · Crystal Structure of the First Bromodomain of Human BRD4 in Complex With Cyclic… · the same entry in another collection · chain A against A, TM-score 1.00
- O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60885
- Elsewhere: RCSB PDB 5ULA · PDBe 5ULA · UniProt O60885
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