MolNFT v1 · #136182 · protein

Structure of apo, semet-labeled cobalamin-dependent S- adenosylmethionine radical enzyme oxsb

5UL2 · Oxsb protein: “Structure of apo, semet-labeled cobalamin-dependent S- adenosylmethionine radical enzyme oxsb”. X-ray diffraction, 7 pockets (best druggability 0.84). MolNFT v1 #136182 on GenesisL1: 3D structure, binding sites and…

PDB: 5UL2
Type: protein
Length: 731 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Oxsb protein
UniProt: O24770
Pockets: 7 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Oxsb protein	protein	731	48% helix, 14% strand	O24770

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 17 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1014	0.84	0.85	111	EDO
2	276	0.69	0.84	45	empty
3	465	0.66	0.78	41	EDO
4	79	0.44	0.80	17	empty
5	58	0.37	0.80	15	empty

Modifications

Observed in the structure: 24 modified, 1 disulfide (engineered, disulfide).

Compared structures

5UL2 · Structure of Apo, SeMet-labeled Cobalamin-dependent S-adenosylmethionine radical enzyme… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O24770
Elsewhere: RCSB PDB 5UL2 · PDBe 5UL2 · UniProt O24770

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