MolNFT v1 · #136070 · protein

Structure of a semisweet D57A mutant

5UHS · Sugar transporter semisweet: “Structure of a semisweet D57A mutant”. X-ray diffraction, 2 ligands (MVC, BGC), 1 pocket (best druggability 0.71). MolNFT v1 #136070 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5UHS
Type: protein
Length: 162 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sugar transporter semisweet
UniProt: B0SR19
Ligands: MVC, BGC
Pockets: 1 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 84% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Sugar transporter semisweet	protein	81	84% helix, 0% strand	B0SR19

Ligands and binding sites

MVC · Monovaccenin · ligand · 2 copies · chains A, B
BGC · beta-D-glucopyranose · sugar · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	380	0.71	0.82	37	BGC

Interfaces

1 interface between chains.

A–B · 1821 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

5UHS · Structure of a SemiSWEET D57A mutant · the same entry in another collection · chain A against A, TM-score 1.00
B0SR19 · AlphaFold monomer V2.0 prediction for sugar transporter semisweet (B0SR19) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B0SR19
Elsewhere: RCSB PDB 5UHS · PDBe 5UHS · UniProt B0SR19

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