MolNFT v1 · #135997 · protein

Crystal structure of a CIP2A core domain

5UFL · Protein CIP2A: “Crystal structure of a CIP2A core domain”. X-ray diffraction, 1 ligand (ZN), 11 pockets (best druggability 0.66). MolNFT v1 #135997 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5UFL
Type: protein
Length: 1,034 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein CIP2A
UniProt: Q8TCG1
Ligands: ZN
Pockets: 11 · best druggability 0.66

Structure

x-ray diffraction · 2 distinct chains · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein CIP2A	protein	523	71% helix, 0% strand	Q8TCG1
B	Protein CIP2A	protein	511	72% helix, 0% strand	Q8TCG1

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	253	0.66	0.83	38	empty
2	212	0.49	0.75	29	empty
3	97	0.48	0.81	22	empty
4	102	0.47	0.80	23	empty
5	110	0.42	0.77	20	empty

Interfaces

1 interface between chains.

A–B · 985 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

5UFL · Crystal structure of a CIP2A core domain · the same entry in another collection · chain B against B, TM-score 1.00
Q8TCG1 · AlphaFold monomer V2.0 prediction for protein CIP2A (Q8TCG1) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TCG1
Elsewhere: RCSB PDB 5UFL · PDBe 5UFL · UniProt Q8TCG1

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