MolNFT v1 · #135948 · protein
Crystal structure of the phosphomannomutase PMM1 from candida albicans, apoenzyme state
5UE7: “Crystal structure of the phosphomannomutase PMM1 from candida albicans, apoenzyme state”. X-ray diffraction, 2 ligands (MG, CL), 3 pockets (best druggability 0.67). MolNFT v1 #135948 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5UE7
- Type
- protein
- Length
- 502 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphomannomutase
- EC
- 5.4.2.8
- UniProt
- P31353
- Ligands
- MG, CL
- Pockets
- 3 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Phosphomannomutase (EC 5.4.2.8) | protein | 251 | 40% helix, 21% strand | P31353 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 633 | 0.67 | 0.76 | 66 | MG |
| 2 | 162 | 0.45 | 0.75 | 27 | empty |
| 3 | 107 | 0.38 | 0.76 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 491 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 5UE7 · Crystal structure of the phosphomannomutase PMM1 from Candida albicans, apoenzyme state · the same entry in another collection · chain A against A, TM-score 1.00
- P31353 · AlphaFold monomer V2.0 prediction for phosphomannomutase (P31353) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31353
- Elsewhere: RCSB PDB 5UE7 · PDBe 5UE7 · UniProt P31353
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