MolNFT v1 · #135894 · protein

Benzophenone synthase from hypericum androsaemum

5UCO · 2,4,6-trihydroxybenzophenone synthase: “Benzophenone synthase from hypericum androsaemum”. X-ray diffraction, 7 pockets (best druggability 0.80). MolNFT v1 #135894 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5UCO
Type: protein
Length: 754 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 2,4,6-trihydroxybenzophenone synthase
EC: 2.3.1.151
UniProt: Q8SAS8
Pockets: 7 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	2,4,6-trihydroxybenzophenone synthase (EC 2.3.1.151)	protein	377	42% helix, 24% strand	Q8SAS8

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	466	0.80	0.87	50	empty
2	484	0.79	0.86	48	empty
3	51	0.45	0.85	16	empty
4	127	0.42	0.76	27	empty
5	133	0.41	0.75	33	empty

Interfaces

1 interface between chains.

A–B · 2532 Å² buried · 33 hydrogen bonds · protein-protein

Compared structures

5UCO · Benzophe synthase from Hypericum androsaemum · the same entry in another collection · chain A against A, TM-score 1.00
Q8SAS8 · AlphaFold monomer V2.0 prediction for 2,4,6-trihydroxybenzophenone synthase (Q8SAS8) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8SAS8
Elsewhere: RCSB PDB 5UCO · PDBe 5UCO · UniProt Q8SAS8

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