MolNFT v1 · #13585 · protein

Crystal structure of the fha domain of the chfr mitotic checkpoint protein complexed with tungstate

1LGP · Cell cycle checkpoint protein chfr: “Crystal structure of the fha domain of the chfr mitotic checkpoint protein complexed with tungstate”. X-ray diffraction, 1 ligand (WO4), 2 pockets (best druggability 0.38). MolNFT v1 #13585 on…

PDB: 1LGP
Type: protein
Length: 113 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cell cycle checkpoint protein chfr
UniProt: Q96EP1
Ligands: WO4
Pockets: 2 · best druggability 0.38

Structure

x-ray diffraction · 1 distinct chain · 3% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cell cycle checkpoint protein chfr	protein	113	3% helix, 28% strand	Q96EP1

Ligands and binding sites

WO4 · Tungstate(vi)ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	126	0.38	0.73	24	empty
2	119	0.37	0.73	14	empty

Compared structures

1LGP · Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
Q96EP1 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase chfr (Q96EP1) · a predicted model of the same protein · chain A against A, TM-score 0.68

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96EP1
Elsewhere: RCSB PDB 1LGP · PDBe 1LGP · UniProt Q96EP1

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