MolNFT v1 · #135815 · protein

Met tyrosine kinase inhibition enhances the antitumor efficacy of an hgf antibody

5UAB · Hepatocyte growth factor receptor: “Met tyrosine kinase inhibition enhances the antitumor efficacy of an hgf antibody”. X-ray diffraction, 2 ligands (84M, CL), 2 pockets (best druggability 0.64). MolNFT v1 #135815 on GenesisL1: 3D…

PDB: 5UAB
Type: protein
Length: 288 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hepatocyte growth factor receptor
EC: 2.7.10.1
UniProt: P08581
Ligands: 84M, CL
Pockets: 2 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hepatocyte growth factor receptor (EC 2.7.10.1)	protein	288	39% helix, 16% strand	P08581

Ligands and binding sites

84M · N-{6-[([1,2,4]triazolo[4,3-a]pyridin-3-yl) sulfanyl]imidazo[1,2-b]pyridazin-2-yl}cyclopropanecarboxamide · ligand · chains A
CL · Chloride ion · ion · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	210	0.64	0.83	28	84M
2	88	0.36	0.75	12	empty

Compared structures

5UAB · MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08581
Elsewhere: RCSB PDB 5UAB · PDBe 5UAB · UniProt P08581

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.