MolNFT v1 · #135759 · protein

A novel family of redox sensors in the streptococci evolved from two- component response regulators

5U8M: “A novel family of redox sensors in the streptococci evolved from two- component response regulators”. X-ray diffraction, 9 pockets (best druggability 0.66). MolNFT v1 #135759 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 5U8M
Type: protein
Length: 458 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Response regulator
UniProt: B1I9H6
Pockets: 9 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Response regulator	protein	229	43% helix, 21% strand	B1I9H6

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	214	0.66	0.84	33	empty
2	156	0.65	0.86	35	empty
3	156	0.56	0.81	23	empty
4	324	0.52	0.74	24	empty
5	156	0.51	0.79	23	empty

Interfaces

1 interface between chains.

A–B · 2433 Å² buried · 29 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

5U8M · A novel family of redox sensors in the streptococci evolved from two-component response… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B1I9H6
Elsewhere: RCSB PDB 5U8M · PDBe 5U8M · UniProt B1I9H6

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