MolNFT v1 · #135757 · protein
Ritr mutant - C128S
5U8K · Response regulator: “Ritr mutant - C128S”. X-ray diffraction, 7 pockets (best druggability 0.53). MolNFT v1 #135757 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5U8K
- Type
- protein
- Length
- 459 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Response regulator
- UniProt
- B1I9H6
- Pockets
- 7 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Response regulator | protein | 229 | 45% helix, 20% strand | B1I9H6 |
| B | Response regulator | protein | 230 | 44% helix, 21% strand | B1I9H6 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 164 | 0.53 | 0.79 | 23 | empty |
| 2 | 162 | 0.50 | 0.78 | 24 | empty |
| 3 | 150 | 0.44 | 0.75 | 19 | empty |
| 4 | 82 | 0.44 | 0.80 | 17 | empty |
| 5 | 95 | 0.43 | 0.78 | 19 | empty |
Modifications
Observed in the structure: 17 modified (engineered).
Compared structures
- 5U8K · RitR mutant - C128S · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B1I9H6
- Elsewhere: RCSB PDB 5U8K · PDBe 5U8K · UniProt B1I9H6
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