MolNFT v1 · #13558 · protein
Crystal structure of oxyb, a cytochrome P450 implicated in an oxidative phenol coupling reaction during vancomycin biosynthesis
1LFK · P450 monooxygenase: “Crystal structure of oxyb, a cytochrome P450 implicated in an oxidative phenol coupling reaction during…”. X-ray diffraction, 1 ligand (HEM), 2 pockets (best druggability 0.81). MolNFT v1 #13558 on GenesisL1: 3D…
- PDB
- 1LFK
- Type
- protein
- Length
- 375 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- P450 monooxygenase
- UniProt
- Q8RN04
- Ligands
- HEM
- Pockets
- 2 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | P450 monooxygenase | protein | 375 | 52% helix, 12% strand | Q8RN04 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 876 | 0.81 | 0.83 | 90 | HEM |
| 2 | 87 | 0.39 | 0.77 | 20 | empty |
Compared structures
- 1LFK · Crystal structure of OxyB, a Cytochrome P450 Implicated in an Oxidative Phenol Coupling… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8RN04 · AlphaFold monomer V2.0 prediction for cytochrome P450 165B3 (Q8RN04) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8RN04
- Elsewhere: RCSB PDB 1LFK · PDBe 1LFK · UniProt Q8RN04
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