MolNFT v1 · #135496 · protein

Crystal structure of DH270.UCA1 (unliganded) from the DH270 broadly neutralizing N332-glycan dependent lineage

5U0R · DH270.UCA1 heavy chain: “Crystal structure of DH270.UCA1 (unliganded) from the DH270 broadly neutralizing N332-glycan dependent lineage”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.67). MolNFT v1 #135496 on…

PDB: 5U0R
Type: protein
Length: 428 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DH270.UCA1 heavy chain; DH270.UCA1 light chain
Ligands: SO4
Pockets: 2 · best druggability 0.67

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	DH270.UCA1 heavy chain	protein	219	4% helix, 49% strand	—
L	DH270.UCA1 light chain	protein	209	5% helix, 45% strand	—

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains H, L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	628	0.67	0.77	67	empty
2	86	0.38	0.76	17	empty

Interfaces

1 interface between chains.

H–L · 1750 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5U0R · Crystal Structure of DH270.UCA1 (unliganded) from the DH270 Broadly Neutralizing… · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5U0R · PDBe 5U0R

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