MolNFT v1 · #135460 · protein
Crystal structure of FPV039:BMF BH3 complex
5TZQ · BCL-2-like protein FPV039: “Crystal structure of FPV039:BMF BH3 complex”. X-ray diffraction, 2 pockets (best druggability 0.57). MolNFT v1 #135460 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TZQ
- Type
- protein
- Length
- 306 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- BCL-2-like protein FPV039; BCL-2-modifying factor
- UniProt
- Q9J5G4, A9XRG9
- Pockets
- 2 · best druggability 0.57
Structure
x-ray diffraction · 4 distinct chains · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | BCL-2-like protein FPV039 | protein | 132 | 79% helix, 0% strand | Q9J5G4 |
| B | BCL-2-like protein FPV039 | protein | 130 | 78% helix, 0% strand | Q9J5G4 |
| C | BCL-2-modifying factor | protein | 22 | 86% helix, 0% strand | A9XRG9 |
| D | BCL-2-modifying factor | protein | 22 | 91% helix, 0% strand | A9XRG9 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 6 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 200 | 0.57 | 0.80 | 28 | EDO |
| 2 | 75 | 0.33 | 0.75 | 15 | empty |
Interfaces
3 interfaces between chains.
- B–C · 924 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 890 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 774 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 5TZQ · Crystal Structure of FPV039:Bmf BH3 complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9J5G4
- Every structure of UniProt A9XRG9
- Elsewhere: RCSB PDB 5TZQ · PDBe 5TZQ · UniProt Q9J5G4 · UniProt A9XRG9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.