MolNFT v1 · #135395 · protein

Hslu P21 cell with 4 hexamers

5TXV · ATP-dependent protease ATPase subunit hslu: “Hslu P21 cell with 4 hexamers”. X-ray diffraction, 1 ligand (ADP), 20 pockets (best druggability 0.87). MolNFT v1 #135395 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5TXV
Type: protein
Length: 8,177 residues
Chains: 24
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATP-dependent protease ATPase subunit hslu
UniProt: P0A6H5
Ligands: ADP
Pockets: 20 · best druggability 0.87

Structure

x-ray diffraction · 24 distinct chains · 60% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ATP-dependent protease ATPase subunit hslu	protein	330	59% helix, 12% strand	P0A6H5
B	ATP-dependent protease ATPase subunit hslu	protein	337	59% helix, 12% strand	P0A6H5
C	ATP-dependent protease ATPase subunit hslu	protein	366	61% helix, 11% strand	P0A6H5
D	ATP-dependent protease ATPase subunit hslu	protein	333	60% helix, 12% strand	P0A6H5
E	ATP-dependent protease ATPase subunit hslu	protein	359	61% helix, 11% strand	P0A6H5
F	ATP-dependent protease ATPase subunit hslu	protein	338	61% helix, 12% strand	P0A6H5
G	ATP-dependent protease ATPase subunit hslu	protein	327	59% helix, 12% strand	P0A6H5
H	ATP-dependent protease ATPase subunit hslu	protein	371	61% helix, 11% strand	P0A6H5
I	ATP-dependent protease ATPase subunit hslu	protein	348	60% helix, 11% strand	P0A6H5
J	ATP-dependent protease ATPase subunit hslu	protein	332	61% helix, 12% strand	P0A6H5
K	ATP-dependent protease ATPase subunit hslu	protein	337	60% helix, 12% strand	P0A6H5
L	ATP-dependent protease ATPase subunit hslu	protein	371	63% helix, 11% strand	P0A6H5
M	ATP-dependent protease ATPase subunit hslu	protein	342	61% helix, 12% strand	P0A6H5
N	ATP-dependent protease ATPase subunit hslu	protein	328	59% helix, 12% strand	P0A6H5
O	ATP-dependent protease ATPase subunit hslu	protein	348	62% helix, 11% strand	P0A6H5
P	ATP-dependent protease ATPase subunit hslu	protein	305	57% helix, 12% strand	P0A6H5
Q	ATP-dependent protease ATPase subunit hslu	protein	370	62% helix, 11% strand	P0A6H5
R	ATP-dependent protease ATPase subunit hslu	protein	338	60% helix, 12% strand	P0A6H5
S	ATP-dependent protease ATPase subunit hslu	protein	310	58% helix, 13% strand	P0A6H5
T	ATP-dependent protease ATPase subunit hslu	protein	318	61% helix, 13% strand	P0A6H5
U	ATP-dependent protease ATPase subunit hslu	protein	321	59% helix, 12% strand	P0A6H5
V	ATP-dependent protease ATPase subunit hslu	protein	352	62% helix, 11% strand	P0A6H5
W	ATP-dependent protease ATPase subunit hslu	protein	336	60% helix, 11% strand	P0A6H5
X	ATP-dependent protease ATPase subunit hslu	protein	360	63% helix, 11% strand	P0A6H5

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · 24 copies · chains A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	934	0.87	0.88	89	ADP
2	1011	0.87	0.88	100	ADP
3	877	0.87	0.89	93	ADP
4	954	0.87	0.88	91	ADP
5	1009	0.86	0.87	93	ADP

Interfaces

34 interfaces between chains.

H–I · 2337 Å² buried · 26 hydrogen bonds · protein-protein
T–U · 2250 Å² buried · 31 hydrogen bonds · protein-protein
B–C · 2212 Å² buried · 23 hydrogen bonds · protein-protein
J–K · 2170 Å² buried · 20 hydrogen bonds · protein-protein
M–N · 2156 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

5TXV · HslU P21 cell with 4 hexamers · the same entry in another collection · chain J against J, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A6H5
Elsewhere: RCSB PDB 5TXV · PDBe 5TXV · UniProt P0A6H5

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