MolNFT v1 · #135349 · protein
Human MOB1A bound to MST1 phosphorylated T367 peptide
5TWH · Mob kinase activator 1A: “Human MOB1A bound to MST1 phosphorylated T367 peptide”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.46). MolNFT v1 #135349 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TWH
- Type
- protein
- Length
- 199 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mob kinase activator 1A; T367 peptide
- UniProt
- Q9H8S9
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 55% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mob kinase activator 1A | protein | 194 | 57% helix, 4% strand | Q9H8S9 |
| E | T367 peptide | protein | 5 | 0% helix, 40% strand | — |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 132 | 0.46 | 0.77 | 20 | empty |
Interfaces
1 interface between chains.
- A–E · 419 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H8S9
- Elsewhere: RCSB PDB 5TWH · PDBe 5TWH · UniProt Q9H8S9
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