MolNFT v1 · #135348 · protein
Human MOB1A bound to human MST1 phosphorylated T353 peptide
5TWG · Mob kinase activator 1A: “Human MOB1A bound to human MST1 phosphorylated T353 peptide”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.44). MolNFT v1 #135348 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5TWG
- Type
- protein
- Length
- 198 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mob kinase activator 1A; T353 peptide
- UniProt
- Q9H8S9
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 60% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mob kinase activator 1A | protein | 193 | 61% helix, 4% strand | Q9H8S9 |
| E | T353 peptide | protein | 5 | 0% helix, 40% strand | — |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 134 | 0.44 | 0.76 | 22 | empty |
Interfaces
1 interface between chains.
- A–E · 399 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H8S9
- Elsewhere: RCSB PDB 5TWG · PDBe 5TWG · UniProt Q9H8S9
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