MolNFT v1 · #135347 · protein

Regulation of protein interactions by MOB1 phosphorylation

5TWF · Mob kinase activator 1A: “Regulation of protein interactions by MOB1 phosphorylation”. X-ray diffraction, 1 ligand (ZN), 2 pockets (best druggability 0.35). MolNFT v1 #135347 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 5TWF
Type: protein
Length: 379 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mob kinase activator 1A
UniProt: Q9H8S9
Ligands: ZN
Pockets: 2 · best druggability 0.35

Structure

x-ray diffraction · 2 distinct chains · 56% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mob kinase activator 1A	protein	189	56% helix, 3% strand	Q9H8S9
B	Mob kinase activator 1A	protein	190	57% helix, 3% strand	Q9H8S9

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	65	0.35	0.77	17	empty
2	70	0.32	0.74	13	empty

Compared structures

5TWF · Regulation of protein interactions by MOB1 phosphorylation · the same entry in another collection · chain A against A, TM-score 1.00
Q9H8S9 · AlphaFold monomer V2.0 prediction for mob kinase activator 1A (Q9H8S9) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H8S9
Elsewhere: RCSB PDB 5TWF · PDBe 5TWF · UniProt Q9H8S9

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