MolNFT v1 · #135274 · protein
Crystal structure of the sus TBC1D15 gap domain
5TUC: “Crystal structure of the sus TBC1D15 gap domain”. X-ray diffraction, 4 pockets (best druggability 0.46). MolNFT v1 #135274 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TUC
- Type
- protein
- Length
- 646 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sus TBC1D15 gap domain
- UniProt
- F1SH24
- Pockets
- 4 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 67% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sus TBC1D15 gap domain | protein | 331 | 64% helix, 1% strand | F1SH24 |
| B | Sus TBC1D15 gap domain | protein | 315 | 70% helix, 1% strand | F1SH24 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 142 | 0.46 | 0.77 | 21 | empty |
| 2 | 236 | 0.46 | 0.73 | 36 | empty |
| 3 | 145 | 0.45 | 0.77 | 23 | empty |
| 4 | 125 | 0.41 | 0.75 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 500 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 5TUC · Crystal Structure of the Sus TBC1D15 GAP Domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt F1SH24
- Elsewhere: RCSB PDB 5TUC · PDBe 5TUC · UniProt F1SH24
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