MolNFT v1 · #13526 · protein
Leucine dehydrogenase from bacillus sphaericus
1LEH: “Leucine dehydrogenase from bacillus sphaericus”. X-ray diffraction, 7 pockets (best druggability 0.70). MolNFT v1 #13526 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1LEH
- Type
- protein
- Length
- 728 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leucine dehydrogenase
- EC
- 1.4.1.9
- UniProt
- Q7SIB4
- Pockets
- 7 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Leucine dehydrogenase (EC 1.4.1.9) | protein | 364 | 47% helix, 16% strand | Q7SIB4 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 717 | 0.70 | 0.77 | 57 | empty |
| 2 | 645 | 0.67 | 0.76 | 51 | empty |
| 3 | 286 | 0.50 | 0.74 | 33 | empty |
| 4 | 266 | 0.49 | 0.74 | 30 | empty |
| 5 | 53 | 0.40 | 0.81 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1364 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 1LEH · Leucine dehydrogenase from bacillus sphaericus · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7SIB4
- Elsewhere: RCSB PDB 1LEH · PDBe 1LEH · UniProt Q7SIB4
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