MolNFT v1 · #135185 · protein
Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase in complex with 2-[(BENZENECARBONYL)AMINO]-3-[(4- CHLOROPHENYL)METHOXY]BENZOIC acid
5TRH: “Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase in complex with…”. X-ray diffraction, 3 ligands (23E, 7HL, SO4). MolNFT v1 #135185 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TRH
- Type
- protein
- Length
- 1,092 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q9WMX2
- Ligands
- 23E, 7HL, SO4
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 550 | — | Q9WMX2 |
| B | — | protein | 542 | — | Q9WMX2 |
Ligands and binding sites
- 23E · (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid · ligand · 2 copies · chains A, B
- 7HL · 2-[(benzenecarbonyl)amino]-3-[(4-chlorophenyl)methoxy]benzoic acid · ligand · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · 10 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5TRH · CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WMX2
- Elsewhere: RCSB PDB 5TRH · PDBe 5TRH · UniProt Q9WMX2
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