MolNFT v1 · #135123 · protein

Crystal structure of DH270.3 (unliganded) from the DH270 broadly neutralizing N332-glycan dependent lineage

5TPL · DH270.3 Fab light chain: “Crystal structure of DH270.3 (unliganded) from the DH270 broadly neutralizing N332-glycan dependent lineage”. X-ray diffraction, 5 pockets (best druggability 0.62). MolNFT v1 #135123 on GenesisL1: 3D…

PDB: 5TPL
Type: protein
Length: 433 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DH270.3 Fab light chain; DH270.3 Fab heavy chain
Pockets: 5 · best druggability 0.62

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	DH270.3 Fab light chain	protein	210	5% helix, 48% strand	—
H	DH270.3 Fab heavy chain	protein	223	8% helix, 49% strand	—

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	554	0.62	0.75	59	empty
2	58	0.38	0.80	21	empty
3	81	0.33	0.74	23	empty
4	76	0.31	0.74	19	empty
5	52	0.30	0.76	16	empty

Interfaces

1 interface between chains.

L–H · 1724 Å² buried · 19 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5TPL · Crystal Structure of DH270.3 (unliganded) from the DH270 Broadly Neutralizing N332-glycan… · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5TPL · PDBe 5TPL

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