MolNFT v1 · #135101 · protein
Botrytis-induced kinase 1 (BIK1) from arabidopsis thaliana
5TOS · SERINE/THREONINE-protein kinase BIK1: “Botrytis-induced kinase 1 (BIK1) from arabidopsis thaliana”. X-ray diffraction, 11 pockets (best druggability 0.49). MolNFT v1 #135101 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5TOS
- Type
- protein
- Length
- 560 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase BIK1
- EC
- 2.7.11.1
- UniProt
- O48814
- Pockets
- 11 · best druggability 0.49
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | SERINE/THREONINE-protein kinase BIK1 (EC 2.7.11.1) | protein | 280 | 41% helix, 14% strand | O48814 |
Pockets
11 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 50 | 0.49 | 0.86 | 15 | empty |
| 2 | 164 | 0.48 | 0.77 | 23 | empty |
| 3 | 64 | 0.48 | 0.84 | 20 | empty |
| 4 | 139 | 0.45 | 0.76 | 19 | empty |
| 5 | 75 | 0.45 | 0.81 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1210 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 5TOS · Botrytis-induced kinase 1 (BIK1) from Arabidopsis thaliana · the same entry in another collection · chain A against A, TM-score 1.00
- O48814 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase BIK1 (O48814) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O48814
- Elsewhere: RCSB PDB 5TOS · PDBe 5TOS · UniProt O48814
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