MolNFT v1 · #134982 · protein

Crystal structure of mouse ISG15

5TLA · Ubiquitin-like protein ISG15: “Crystal structure of mouse ISG15”. X-ray diffraction, 19 pockets (best druggability 0.83). MolNFT v1 #134982 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5TLA
Type: protein
Length: 1,457 residues
Chains: 10
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin-like protein ISG15
UniProt: Q64339
Pockets: 19 · best druggability 0.83

Structure

x-ray diffraction · 7 distinct chains · 23% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, F	Ubiquitin-like protein ISG15	protein	151	25% helix, 34% strand	Q64339
C, E	Ubiquitin-like protein ISG15	protein	150	21% helix, 36% strand	Q64339
D	Ubiquitin-like protein ISG15	protein	144	23% helix, 35% strand	Q64339
G	Ubiquitin-like protein ISG15	protein	143	24% helix, 31% strand	Q64339
H	Ubiquitin-like protein ISG15	protein	142	20% helix, 30% strand	Q64339
I	Ubiquitin-like protein ISG15	protein	135	24% helix, 32% strand	Q64339
J	Ubiquitin-like protein ISG15	protein	140	22% helix, 34% strand	Q64339

Pockets

19 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1037	0.83	0.85	120	empty
2	603	0.76	0.82	63	empty
3	587	0.75	0.82	57	empty
4	641	0.74	0.80	54	empty
5	541	0.72	0.81	49	empty

Interfaces

12 interfaces between chains.

F–H · 1008 Å² buried · 9 hydrogen bonds · protein-protein
A–C · 989 Å² buried · 7 hydrogen bonds · protein-protein
H–J · 917 Å² buried · 9 hydrogen bonds · protein-protein
A–B · 899 Å² buried · 10 hydrogen bonds · protein-protein
F–G · 898 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

5TLA · Crystal structure of mouse ISG15 · the same entry in another collection · chain J against J, TM-score 1.00
Q64339 · AlphaFold monomer V2.0 prediction for ubiquitin-like protein ISG15 (Q64339) · a predicted model of the same protein · chain J against A, TM-score 0.71

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q64339
Elsewhere: RCSB PDB 5TLA · PDBe 5TLA · UniProt Q64339

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