MolNFT v1 · #134975 · protein + DNA
Mec-8 N-terminal rrm bound to tandem gcac ligand
5TKZ · Mec-8 protein: “Mec-8 N-terminal rrm bound to tandem gcac ligand”. X-ray diffraction, 1 pocket (best druggability 0.50). MolNFT v1 #134975 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TKZ
- Type
- protein + DNA
- Length
- 188 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mec-8 protein; DNA (5'- D(*AP*GP*CP*AP*CP*AP*TP*TP*TP*TP*TP*TP*TP*TP*AP*GP*CP*AP*CP*A)-3')
- UniProt
- Q22039
- Pockets
- 1 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 21% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Mec-8 protein | protein | 89 | 21% helix, 37% strand | Q22039 |
| C | DNA (5'- D(*AP*GP*CP*AP*CP*AP*TP*TP*TP*TP*TP*TP*TP*TP*AP*GP*CP*AP*CP*A)-3') | dna | 10 | — | — |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 154 | 0.50 | 0.79 | 25 | empty |
Interfaces
3 interfaces between chains.
- A–B · 733 Ų buried · 19 hydrogen bonds · protein-protein
- B–C · 597 Ų buried · 19 hydrogen bonds · protein-nucleic
- A–C · 596 Ų buried · 18 hydrogen bonds · protein-nucleic
Compared structures
- 5TKZ · MEC-8 N-terminal RRM bound to tandem GCAC ligand · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q22039
- Elsewhere: RCSB PDB 5TKZ · PDBe 5TKZ · UniProt Q22039
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