MolNFT v1 · #134955 · protein
Crystal structure of eukaryotic hydrolase
5TKE · O-glcnacase: chimera construct: “Crystal structure of eukaryotic hydrolase”. X-ray diffraction, 7 pockets (best druggability 0.81). MolNFT v1 #134955 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TKE
- Type
- protein
- Length
- 842 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- O-glcnacase: chimera construct
- EC
- 3.2.1.169, 3.2.1.-
- UniProt
- O60502
- Pockets
- 7 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | O-glcnacase: chimera construct (EC 3.2.1.169, 3.2.1.-) | protein | 420 | 50% helix, 9% strand | O60502 |
| B | O-glcnacase: chimera construct (EC 3.2.1.169, 3.2.1.-) | protein | 422 | 51% helix, 9% strand | O60502 |
Pockets
7 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 806 | 0.81 | 0.84 | 63 | empty |
| 2 | 412 | 0.67 | 0.79 | 50 | empty |
| 3 | 83 | 0.60 | 0.89 | 17 | empty |
| 4 | 293 | 0.57 | 0.76 | 34 | empty |
| 5 | 74 | 0.50 | 0.85 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 3514 Ų buried · 34 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60502
- Elsewhere: RCSB PDB 5TKE · PDBe 5TKE · UniProt O60502
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