MolNFT v1 · #134938 · protein

Influenza a virus nucleoprotein in complex with inhibitory nanobody

5TJW: “Influenza a virus nucleoprotein in complex with inhibitory nanobody”. X-ray diffraction, 10 pockets (best druggability 0.78). MolNFT v1 #134938 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5TJW
Type: protein
Length: 589 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleoprotein; Np-specific inhibitory vhh
UniProt: B4URF1
Pockets: 10 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleoprotein	protein	467	48% helix, 8% strand	B4URF1
K	Np-specific inhibitory vhh	protein	122	8% helix, 46% strand	—

Pockets

10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	857	0.78	0.81	61	empty
2	219	0.53	0.77	28	empty
3	183	0.42	0.73	19	empty
4	75	0.36	0.76	16	empty
5	72	0.35	0.76	18	empty

Interfaces

1 interface between chains.

A–K · 577 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

5TJW · Influenza A virus Nucleoprotein in Complex with Inhibitory Nanobody · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B4URF1
Elsewhere: RCSB PDB 5TJW · PDBe 5TJW · UniProt B4URF1

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