MolNFT v1 · #134921 · protein

I-II linker of TRPML1 channel at pH 4.5

5TJB · Mucolipin-1: “I-II linker of TRPML1 channel at pH 4.5”. X-ray diffraction, 1 pocket (best druggability 0.31). MolNFT v1 #134921 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5TJB
Type: protein
Length: 156 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mucolipin-1
UniProt: Q9GZU1
Pockets: 1 · best druggability 0.31

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mucolipin-1	protein	156	26% helix, 36% strand	Q9GZU1

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	51	0.31	0.77	12	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

5TJB · I-II linker of TRPML1 channel at pH 4.5 · the same entry in another collection · chain A against A, TM-score 1.00
Q9GZU1 · AlphaFold monomer V2.0 prediction for mucolipin-1 (Q9GZU1) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9GZU1
Elsewhere: RCSB PDB 5TJB · PDBe 5TJB · UniProt Q9GZU1

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