MolNFT v1 · #134851 · protein
GEMIN5 WD40 repeats in complex with a guanosyl moiety
5THA · Gem-associated protein 5: “GEMIN5 WD40 repeats in complex with a guanosyl moiety”. X-ray diffraction, 2 ligands (GP3, UNX), 6 pockets (best druggability 0.79). MolNFT v1 #134851 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5THA
- Type
- protein
- Length
- 684 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gem-associated protein 5
- UniProt
- Q8TEQ6
- Ligands
- GP3, UNX
- Pockets
- 6 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 5% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gem-associated protein 5 | protein | 684 | 5% helix, 46% strand | Q8TEQ6 |
Ligands and binding sites
- GP3 · Diguanosine-5'-triphosphate · ligand · chains A
- UNX · Unknown atom or ion · ion · 21 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 971 | 0.79 | 0.80 | 64 | UNX, GP3 |
| 2 | 526 | 0.77 | 0.84 | 53 | UNX |
| 3 | 366 | 0.59 | 0.77 | 39 | empty |
| 4 | 215 | 0.51 | 0.76 | 34 | empty |
| 5 | 59 | 0.34 | 0.77 | 14 | UNX |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TEQ6
- Elsewhere: RCSB PDB 5THA · PDBe 5THA · UniProt Q8TEQ6
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