MolNFT v1 · #134777 · protein

Crystal structure of the WD40 domain of the human prolactin regulatory element-binding protein

5TF2: “Crystal structure of the WD40 domain of the human prolactin regulatory element-binding protein”. X-ray diffraction, 1 ligand (UNX), 2 pockets (best druggability 0.77). MolNFT v1 #134777 on GenesisL1: 3D structure, binding sites and…

PDB: 5TF2
Type: protein
Length: 338 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Prolactin regulatory element-binding protein
UniProt: Q9HCU5
Ligands: UNX
Pockets: 2 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 55% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Prolactin regulatory element-binding protein	protein	338	2% helix, 55% strand	Q9HCU5

Ligands and binding sites

UNX · Unknown atom or ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	846	0.77	0.80	72	empty
2	52	0.34	0.78	17	empty

Compared structures

5TF2 · Crystal structure of the WD40 domain of the human prolactin regulatory element-binding… · the same entry in another collection · chain A against A, TM-score 1.00
Q9HCU5 · AlphaFold monomer V2.0 prediction for prolactin regulatory element- binding protein… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HCU5
Elsewhere: RCSB PDB 5TF2 · PDBe 5TF2 · UniProt Q9HCU5

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