MolNFT v1 · #134710 · protein

C. elegans fog-3 BTG/TOB domain - H47N, C117A

5TD6 · Fog-3 protein: “C. elegans fog-3 BTG/TOB domain - H47N, C117A”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.70). MolNFT v1 #134710 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5TD6
Type: protein
Length: 260 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fog-3 protein
UniProt: G5EDX7
Ligands: SO4
Pockets: 4 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fog-3 protein	protein	124	44% helix, 19% strand	G5EDX7
B	Fog-3 protein	protein	136	46% helix, 15% strand	G5EDX7

Ligands and binding sites

SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	334	0.70	0.83	30	empty
2	365	0.65	0.80	32	empty
3	90	0.44	0.80	17	empty
4	102	0.36	0.73	13	empty

Interfaces

1 interface between chains.

A–B · 1096 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

5TD6 · C. elegans FOG-3 BTG/Tob domain - H47N, C117A · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G5EDX7
Elsewhere: RCSB PDB 5TD6 · PDBe 5TD6 · UniProt G5EDX7

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