MolNFT v1 · #134699 · protein
Near-atomic resolution cryo-EM structure of the salmonella spi-1 type III secretion injectisome secretin invg
5TCQ · Protein invg: “Near-atomic resolution cryo-EM structure of the salmonella spi-1 type III secretion injectisome secretin invg”. Electron microscopy, 20 pockets (best druggability 0.88). MolNFT v1 #134699 on GenesisL1: 3D structure…
- PDB
- 5TCQ
- Type
- protein
- Length
- 5,040 residues
- Chains
- 15
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein invg
- UniProt
- P35672
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 1 distinct chain · 17% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O | Protein invg | protein | 336 | 17% helix, 53% strand | P35672 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 789 | 0.88 | 0.91 | 132 | empty |
| 2 | 433 | 0.83 | 0.91 | 68 | empty |
| 3 | 438 | 0.83 | 0.91 | 68 | empty |
| 4 | 391 | 0.83 | 0.91 | 69 | empty |
| 5 | 390 | 0.83 | 0.91 | 68 | empty |
Interfaces
30 interfaces between chains.
- A–O · 4869 Ų buried · 78 hydrogen bonds · protein-protein
- J–K · 4864 Ų buried · 78 hydrogen bonds · protein-protein
- G–H · 4861 Ų buried · 78 hydrogen bonds · protein-protein
- K–L · 4861 Ų buried · 78 hydrogen bonds · protein-protein
- H–I · 4859 Ų buried · 78 hydrogen bonds · protein-protein
Compared structures
- P35672 · AlphaFold monomer V2.0 prediction for spi-1 type 3 secretion system secretin (P35672) · a predicted model of the same protein · chain A against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35672
- Elsewhere: RCSB PDB 5TCQ · PDBe 5TCQ · UniProt P35672
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