MolNFT v1 · #13454 · protein
Crystal structure of a biliverdin reductase enzyme-cofactor complex
1LC3 · Biliverdin reductase a: “Crystal structure of a biliverdin reductase enzyme-cofactor complex”. X-ray diffraction, 2 ligands (NAD, PO4), 4 pockets (best druggability 0.63). MolNFT v1 #13454 on GenesisL1: 3D structure, binding sites…
- PDB
- 1LC3
- Type
- protein
- Length
- 292 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Biliverdin reductase a
- EC
- 1.3.1.24
- UniProt
- P46844
- Ligands
- NAD, PO4
- Pockets
- 4 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Biliverdin reductase a (EC 1.3.1.24) | protein | 292 | 41% helix, 27% strand | P46844 |
Ligands and binding sites
- NAD · Nicotinamide-adenine-dinucleotide · ligand · 2 copies · chains A
- PO4 · Phosphate ion · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 495 | 0.63 | 0.76 | 48 | PO4, NAD |
| 2 | 77 | 0.46 | 0.81 | 16 | empty |
| 3 | 116 | 0.39 | 0.75 | 20 | empty |
| 4 | 93 | 0.38 | 0.76 | 16 | empty |
Compared structures
- 1LC3 · Crystal Structure of a Biliverdin Reductase Enzyme-Cofactor Complex · the same entry in another collection · chain A against A, TM-score 1.00
- P46844 · AlphaFold monomer V2.0 prediction for biliverdin reductase a (P46844) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46844
- Elsewhere: RCSB PDB 1LC3 · PDBe 1LC3 · UniProt P46844
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