MolNFT v1 · #134511 · protein
Crystal structure of aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a dichloro-dimethylpyridyl-methoxy- phenyl-pyridyl-piperazine ligand
5T6E · Glycylpeptide N-tetradecanoyltransferase: “Crystal structure of aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a…”. X-ray diffraction, 2 ligands (MYA, 75R), 2 pockets (best druggability 0.77). MolNFT…
- PDB
- 5T6E
- Type
- protein
- Length
- 392 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycylpeptide N-tetradecanoyltransferase
- EC
- 2.3.1.97
- UniProt
- Q9UVX3
- Ligands
- MYA, 75R
- Pockets
- 2 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97) | protein | 392 | 29% helix, 30% strand | Q9UVX3 |
Ligands and binding sites
- MYA · Tetradecanoyl-coa · ligand · chains A
- 75R · 1-(4-{3,5-dichloro-4-[(2,4-dimethylpyridin-3-yl) methoxy]phenyl}pyridin-2-yl)piperazine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 835 | 0.77 | 0.81 | 89 | MYA, 75R |
| 2 | 81 | 0.41 | 0.79 | 17 | empty |
Compared structures
- 5T6E · Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UVX3 · AlphaFold monomer V2.0 prediction for glycylpeptide N-tetradecanoyltransferase (Q9UVX3) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UVX3
- Elsewhere: RCSB PDB 5T6E · PDBe 5T6E · UniProt Q9UVX3
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